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Muramyl dipeptide
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. It indirectly decreases osteoclast differentiation by reducing the RANKL/OPG ratio and directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways, thereby inducing bone formation via Runx2.
Catalog No. T16159Cas No. 53678-77-6
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ee:100%
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Muramyl dipeptide
Catalog No. T16159Alias MDPCas No. 53678-77-6
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. It indirectly decreases osteoclast differentiation by reducing the RANKL/OPG ratio and directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways, thereby inducing bone formation via Runx2.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $207 | In Stock | |
| 5 mg | $336 | In Stock | |
| 10 mg | $520 | In Stock | |
| 25 mg | $893 | In Stock | |
| 50 mg | $1,270 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $370 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. It indirectly decreases osteoclast differentiation by reducing the RANKL/OPG ratio and directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways, thereby inducing bone formation via Runx2. |
| In vitro | Muramyl dipeptide increases the protein expression of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 24 hours)[1]. It also enhances the mRNA levels of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 6 hours)[2]. Muramyl dipeptide indirectly attenuates osteoclast differentiation by reducing the RANKL/OPG ratio[2]. |
| In vivo | Muramyl dipeptide can be used for animal modeling to establish sepsis models. Muramyl dipeptide (1.25 mg/kg; intraperitoneal injection; twice) alleviates osteoporosis-induced bone loss[2]. |
| Alias | MDP |
| Molecular Weight | 492.48 |
| Formula | C19H32N4O11 |
| Cas No. | 53678-77-6 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (101.53 mM), Sonication is recommended. H2O: 20 mg/mL (40.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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