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Myosin V-IN-1

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Purity:97.31%

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COA HNMR HPLC LCMS

Myosin V-IN-1

Catalog No. T72060Cas No. 1259177-59-7

Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.

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Pack Size	Price	Availability
1 mg	$330	In Stock
5 mg	$698	In Stock
10 mg	$993	In Stock
25 mg	$1,470	In Stock
50 mg	$1,990	In Stock
100 mg	$2,680	In Stock
1 mL x 10 mM (in DMSO)	$713	In Stock

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Product Introduction

Bioactivity

Description	Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
Targets&IC50	Myosin V:6 μM(Ki)
In vitro	Myosin V-IN-1 (compound 8) exhibits a dose-dependent decrease in the rate of actin-activated ATP hydrolysis by single-headed myosin V.[1]

Chemical Properties

Molecular Weight	538.62
Formula	C29H26N6O3S
Cas No.	1259177-59-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (167.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8566 mL	9.2830 mL	18.5660 mL	92.8298 mL
5 mM	0.3713 mL	1.8566 mL	3.7132 mL	18.5660 mL
10 mM	0.1857 mL	0.9283 mL	1.8566 mL	9.2830 mL
20 mM	0.0928 mL	0.4641 mL	0.9283 mL	4.6415 mL
50 mM	0.0371 mL	0.1857 mL	0.3713 mL	1.8566 mL
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Myosin V-IN-1

Myosin V-IN-1

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Product Introduction

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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