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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $263 | In Stock | |
5 mg | $788 | In Stock | |
10 mg | $1,260 | In Stock | |
25 mg | $1,870 | In Stock | |
50 mg | $2,530 | In Stock | |
100 mg | $3,390 | In Stock |
Description | NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23. |
In vitro | NDI-034858 (compound I-908) (10 μM) demonstrates inhibitory activity against Tyk2 and JAK enzymes. It achieves this by targeting the Tyk2 JH1 domain and the JAK JH1 domain, resulting in inhibition rates of less than 50% for both enzymes.[2] |
Alias | TAK-279, NDI-03485 |
Molecular Weight | 460.49 |
Formula | C23H24N8O3 |
Cas No. | 2272904-53-5 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (97.7 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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