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ERGi-USU

Name: ERGi-USU
Brand: TargetMol
SKU: T7145
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

Catalog No. T7145Cas No. 1147-56-4

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Purity:≥95%

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COA HNMR

ERGi-USU

Catalog No. T7145Cas No. 1147-56-4

NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
100 mg	$41	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein.
Targets&IC50	ERG (positive cancer cells):30 to 400 nM (IC50)
In vitro	ERGi-USU selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines.?The IC50 of ERGi-USU for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM[1].

Chemical Properties

Molecular Weight	255.3
Formula	C₁₃H₉N₃OS
Cas No.	1147-56-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 62 mg/mL (242.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9170 mL	19.5848 mL	39.1696 mL	195.8480 mL
5 mM	0.7834 mL	3.9170 mL	7.8339 mL	39.1696 mL
10 mM	0.3917 mL	1.9585 mL	3.9170 mL	19.5848 mL
20 mM	0.1958 mL	0.9792 mL	1.9585 mL	9.7924 mL
50 mM	0.0783 mL	0.3917 mL	0.7834 mL	3.9170 mL
100 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9585 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitNSC-139021NSC 139021NSC139021