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NU 9056

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Purity:95.36%

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COA HNMR LCMS

NU 9056

Catalog No. T23095Cas No. 1450644-28-6

NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.

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Pack Size	Price	Availability	Quantity
1 mg	$149	In Stock

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Product Introduction

Bioactivity

Description	NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
In vitro	NU 9056 shows IC50s of 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. In LNCaP cells, NU 9056 (17 µM, 24 µM, 36 µM) activates both caspase 3 and caspase 9 in a time- and concentration-dependent manner thereby inducing apoptosis. NU 9056 (2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM) decreases the levels of acetylated histone H4K16, H3K14 and H4K8. NU 9056 causes a reduction of androgen receptor, prostate specific antigen, p53 and p21 protein levels[2].
In vivo	In mice, NU 9056 (2 μg/g) inhibits Tip60 and reduces H2A.Z binding at the the +1 nucleosome of Arc and Syp and the -1 nucleosome of Arc. NU 9056 increases the acetylation at the +1 nucleosome of Gria4 and the -1 nucleosome of Fos, Tacstd2, and Gria4[1].
Alias	NU9056

Chemical Properties

Molecular Weight	232.37
Formula	C6H4N2S4
Cas No.	1450644-28-6

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (484.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3035 mL	21.5174 mL	43.0348 mL	215.1741 mL
5 mM	0.8607 mL	4.3035 mL	8.6070 mL	43.0348 mL
10 mM	0.4303 mL	2.1517 mL	4.3035 mL	21.5174 mL
20 mM	0.2152 mL	1.0759 mL	2.1517 mL	10.7587 mL
50 mM	0.0861 mL	0.4303 mL	0.8607 mL	4.3035 mL
100 mM	0.0430 mL	0.2152 mL	0.4303 mL	2.1517 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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