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CPI-637

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Purity:99.91%

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COA HNMR LCMS HPLC

CPI-637

Catalog No. T6811Cas No. 1884712-47-3

CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$71	In Stock
10 mg	$102	In Stock
25 mg	$223	In Stock
50 mg	$397	In Stock
100 mg	$597	In Stock
500 mg	$1,260	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Product Introduction

Bioactivity

Description	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
In vitro	CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1].
Kinase Assay	Ki Determination: Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis.
Cell Research	AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 μM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference)
Alias	CPI 637

Chemical Properties

Molecular Weight	386.45
Formula	C22H22N6O
Cas No.	1884712-47-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.87 mg/mL (10 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2588 mL	1.2938 mL	2.5877 mL	12.9383 mL
20 mM	0.1294 mL	0.6469 mL	1.2938 mL	6.4691 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL	2.5877 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2938 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc