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Remodelin hydrobromide

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Purity:99.84%

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COA HNMR HPLC

Remodelin hydrobromide

Catalog No. T6133Cas No. 1622921-15-6

Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.

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Pack Size	Price	Availability
5 mg	$52	In Stock
10 mg	$79	In Stock
25 mg	$148	In Stock
50 mg	$262	In Stock
100 mg	$392	In Stock
200 mg	$575	In Stock
500 mg	$886	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Product Introduction

Bioactivity

Description	Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
In vivo	Remodelin restores nuclear morphology and enhances the resilience of the nucleus in HGPS cells by depleting LMNA through microtubule reorganization, mediated by its inhibition of NAT10.
Alias	Remodelin, Remodelin HBR

Chemical Properties

Molecular Weight	363.28
Formula	C15H15BrN4S
Cas No.	1622921-15-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (110.11 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7527 mL	13.7635 mL	27.5270 mL	137.6349 mL
5 mM	0.5505 mL	2.7527 mL	5.5054 mL	27.5270 mL
10 mM	0.2753 mL	1.3763 mL	2.7527 mL	13.7635 mL
20 mM	0.1376 mL	0.6882 mL	1.3763 mL	6.8817 mL
50 mM	0.0551 mL	0.2753 mL	0.5505 mL	2.7527 mL
100 mM	0.0275 mL	0.1376 mL	0.2753 mL	1.3763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc