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NVP-BAG956

🥰Excellent
Catalog No. TQ0313Cas No. 853910-02-8
Alias NVPBAG956, BAG956, BAG 956

NVP-BAG956 (BAG956) is a potent PI3K/PDK inhibitor that inhibits PI3Kδ, PI3Kα, PI3Kγ, and PI3Kβ, shows strong cytotoxicity against T-ALL cell lines, and can be used to study melanoma.

NVP-BAG956

NVP-BAG956

🥰Excellent
Purity: 99.80%
Catalog No. TQ0313Alias NVPBAG956, BAG956, BAG 956Cas No. 853910-02-8
NVP-BAG956 (BAG956) is a potent PI3K/PDK inhibitor that inhibits PI3Kδ, PI3Kα, PI3Kγ, and PI3Kβ, shows strong cytotoxicity against T-ALL cell lines, and can be used to study melanoma.
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50 mg$747In Stock
100 mg$1,360In Stock
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Purity:99.80%
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Product Introduction

Bioactivity
Description
NVP-BAG956 (BAG956) is a potent PI3K/PDK inhibitor that inhibits PI3Kδ, PI3Kα, PI3Kγ, and PI3Kβ, shows strong cytotoxicity against T-ALL cell lines, and can be used to study melanoma.
Targets&IC50
VEGFR1:2.56 μM, PDK1:240 nM, pAkt:67 nM, A2058 cells:290 nM
In vitro
NVP-BAG956 inhibited PDK1 (IC50: 240 nM) and VEGFR1 (IC50: 2.56 μM). It also blocked the phosphorylation of PKB/Akt in A2058 cells with an IC50 of 67 nM.The inhibition of PKB/Akt phosphorylation was closely correlated with the reduction of A2058 cell proliferation, with an IC50 of 290 nM for NVP-BAG956.In the presence of NVP-BAG956, the A2058 cells were only able to exit from the G2-M phase, and thereafter stayed in the G1 phase. In addition, NVP-BAG956 significantly induced the expression of p27Kip1 in A2058 cells, but not in C32 cells. [1]
Cell Research
One day after plating (7×10^3 cells/cm2), melanoma cells (A2058, B16F1, B16F10, C32, HBL, Malme, Malme3M, NA8, SKMel2, SKMel23, A375, Hs294T, WM35, and 1205lu cells) are exposed to LY294002 (25 μM), Wortmannin (500 nM), NVP-BAG956 (1 μM), NVP-BBD130 (1 μM), NVP-BEZ235 (1 μM), and ZSTK474 (1 μM), and Rapamycin (100 nM). Compound concentrations are set 2 log units above the IC50 in vitro to ensure full PI3K inhibition, except for the μM inhibitor LY294002. Cells are trypsinized and counted, and the volume is quantified using a Casy Counter and Analyser. To determine the nuclear volume, cells are resuspended in CASYton containing 0.5% Triton X-100, followed by repetitive pipetting (8×), before volume measurements.
AliasNVPBAG956, BAG956, BAG 956
Chemical Properties
Molecular Weight427.5
FormulaC28H21N5
Cas No.853910-02-8
SmilesN#CC(C1=CC=C(C=C1)N2C(=NC=3C=NC=4C=CC(C#CC=5C=NC=CC5)=CC4C32)C)(C)C
Relative Density.1.17 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (93.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3392 mL11.6959 mL23.3918 mL116.9591 mL
5 mM0.4678 mL2.3392 mL4.6784 mL23.3918 mL
10 mM0.2339 mL1.1696 mL2.3392 mL11.6959 mL
20 mM0.1170 mL0.5848 mL1.1696 mL5.8480 mL
50 mM0.0468 mL0.2339 mL0.4678 mL2.3392 mL

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