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ONO-RS-082

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Purity:99.32%

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COA HPLC HNMR

ONO-RS-082

Catalog No. T21815Cas No. 99754-06-0

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.

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Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$236	In Stock
50 mg	$428	In Stock
100 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Questions

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Product Introduction

Bioactivity

Description	ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.
In vitro	ONO-RS-082 at 3.5 μM was able to inhibit epinephrine-stimulated thromboxane production in human platelets.?ONO-RS-082 could also disrupt endosome tubule formation and maintenance of the Golgi complex[1].

Chemical Properties

Molecular Weight	371.86
Formula	C21H22ClNO3
Cas No.	99754-06-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (80.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6892 mL	13.4459 mL	26.8918 mL	134.4592 mL
5 mM	0.5378 mL	2.6892 mL	5.3784 mL	26.8918 mL
10 mM	0.2689 mL	1.3446 mL	2.6892 mL	13.4459 mL
20 mM	0.1345 mL	0.6723 mL	1.3446 mL	6.7230 mL
50 mM	0.0538 mL	0.2689 mL	0.5378 mL	2.6892 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

lungneutrophilshepoxilinONO RS 082prostaglandinarachidonicONO-RS082ONO-RS 082inhibitinflammationPhospholipaseInhibitorONORS082acidONO-RS-082