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ONT-093
🥰Excellent
Catalog No. T63338Cas No. 216227-54-2
Alias ONT093, OC144 093, OC 144-093, OC 144093
ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.
ONT-093
🥰Excellent
Catalog No. T63338Alias ONT093, OC144 093, OC 144-093, OC 144093Cas No. 216227-54-2
ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $92 | In Stock | |
| 10 mg | $133 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes. |
| Targets&IC50 | P-gp:0.032 μM (EC50) |
| In vitro | ONT-093 is an orally active, potent, and non-toxic P-GP-mediated multidrug resistance inhibitor. ONT-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal cancer cell lines expressing P-glycoprotein (P-gp), with a mean EC50 of 0.032 μM. ONT-093 blocked the binding of [3H] azzapine to P-glycoprotein and inhibited P-glycoprotein ATPase activity. [1] |
| In vivo | ONT-093 extended the lifespan of doxorubicin-treated mice implanted with MDR P388 leukemia cells by >100% and significantly enhanced the in vivo anti-tumor activity of paclitaxel in MDR human breast and colon cancer xenotransplantation models. [1] |
| Alias | ONT093, OC144 093, OC 144-093, OC 144093 |
| Molecular Weight | 494.67 |
| Formula | C32H38N4O |
| Cas No. | 216227-54-2 |
| Smiles | N(C(C)C)C1=CC=C(C2=C(N=C(N2)C3=CC=C(/C=C/COCC)C=C3)C4=CC=C(NC(C)C)C=C4)C=C1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Methanol: 100 mg/mL (202.15 mM), Sonication is recommended. DMSO: 80 mg/mL (161.72 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Methanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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