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Orexin A (human, rat, mouse) acetate

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Catalog No. T73658
Alias Hypocretin-1 (human, rat, mouse) acetate

Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.

Orexin A (human, rat, mouse) acetate

Orexin A (human, rat, mouse) acetate

🥰Excellent
Catalog No. T73658Alias Hypocretin-1 (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.
Pack SizePriceAvailabilityQuantity
1 mg$196 In Stock
5 mg$370 In Stock
10 mg$445 In Stock
25 mg$835 In Stock
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Product Introduction

Bioactivity
Description
Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.
In vitro
Orexin A (human, rat, mouse) acetate (0.1, 1, 10, 100 nM, 24h) increased the expression of BDNF in SH-SY5Y human dopaminergic neuroblastoma cells. [1]
Orexin A (human, rat, mouse) acetate (5μM) therapy alleviated the decrease in the number of MC3T3-E1 cells and OCN expression induced by chronic intermittent hypoxia (CIH) by combining with OX1R. [2]
In vivo
Orexin A (human, rat, mouse) acetate(300 ng/ mouse, injected into the brain) significantly improved spatial learning and memory impairment in MPTP-induced Parkinson's disease mouse models. [1]
Orexin A (human, rat, mouse) acetate treatment improved bone formation in CIH mice. [2]
AliasHypocretin-1 (human, rat, mouse) acetate
Chemical Properties
Molecular Weight3621.15
FormulaC154H247N47O46S4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 40 mg/mL (11.05 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.2762 mL1.3808 mL2.7616 mL13.8078 mL
5 mM0.0552 mL0.2762 mL0.5523 mL2.7616 mL
10 mM0.0276 mL0.1381 mL0.2762 mL1.3808 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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