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p-Ethynylphenylalanine hydrochloride
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].
Catalog No. T10142LCas No. 188640-63-3
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Purity:99.03%
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p-Ethynylphenylalanine hydrochloride
Catalog No. T10142LAlias p-Ethynylphenylalanine hydrochloride(278605-15-5 free base), 4-Ethynyl-L-phenylalanine HCLCas No. 188640-63-3
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $30 | In Stock | |
| 25 mg | $45 | In Stock | |
| 50 mg | $64 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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p-Ethynylphenylalanine
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Product Introduction
Bioactivity
Chemical Properties
| Description | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1]. |
| Targets&IC50 | TPH:32.6 μM |
| In vitro | p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan)[1]. |
| In vivo | Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection[1]. |
| Alias | p-Ethynylphenylalanine hydrochloride(278605-15-5 free base), 4-Ethynyl-L-phenylalanine HCL |
| Molecular Weight | 225.67 |
| Formula | C11H12ClNO2 |
| Cas No. | 188640-63-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 12 mg/mL (53.17 mM), Sonication is recommended. DMSO: 99 mg/mL (438.69 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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