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PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $81 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $313 | In Stock | |
25 mg | $519 | In Stock | |
50 mg | $745 | In Stock | |
100 mg | $1,070 | In Stock |
Description | PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer. |
In vitro | PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1] |
In vivo | Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1]. |
Molecular Weight | 310.37 |
Formula | C17H14N2O2S |
Cas No. | 444930-42-1 |
Smiles | Cc1ccsc1C(=O)N\N=C\c1ccc2ccccc2c1O |
Relative Density. | 1.30 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 3.1 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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