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PF-04957325
PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.
Catalog No. T12422Cas No. 1305115-80-3
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Purity:99.02%
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PF-04957325
Catalog No. T12422Cas No. 1305115-80-3
PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $139 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $643 | In Stock | |
| 50 mg | $932 | In Stock | |
| 100 mg | $1,390 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $217 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis. |
| Targets&IC50 | PDE8B:0.2 nM, PDE8A:0.7 nM |
| In vitro | The PDE8 selective inhibitor PF-04957325 exhibits an IC50 of 0.7 nM for PDE8A and 0.2 nM for PDE8B, while its IC50 for all other PDE isoforms is greater than 1.5 μM [3]. Treatment with PF-04957325 in WT Leydig cells or MA10 cells increases steroid production, but has no effect in PDE8A(-/-)/B(-/-) double knockout cells, indicating the drug's specificity [4]. |
| Molecular Weight | 400.38 |
| Formula | C14H15F3N8OS |
| Cas No. | 1305115-80-3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (200 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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