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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $212 | In Stock | |
5 mg | $538 | In Stock | |
10 mg | $778 | In Stock | |
25 mg | $1,180 | In Stock | |
50 mg | $1,620 | In Stock |
Description | Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia. |
In vitro | Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM. LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2]. |
In vivo | Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1]. |
Alias | LY2140023 hydrochloride |
Molecular Weight | 402.87 |
Formula | C12H19ClN2O7S2 |
Cas No. | 635318-26-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (55.8 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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