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Pramiconazole

🥰Excellent
Catalog No. T25982Cas No. 219923-85-0
Alias R-126638, R126638, R 126638, Azoline

Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.

Pramiconazole

Pramiconazole

🥰Excellent
Purity: 98.84%
Catalog No. T25982Alias R-126638, R126638, R 126638, AzolineCas No. 219923-85-0
Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.
Pack SizePriceAvailabilityQuantity
1 mg515 €In Stock
5 mg1.149 €In Stock
10 mg1.548 €In Stock
25 mg2.270 €In Stock
50 mg3.097 €In Stock
100 mg4.161 €In Stock
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Purity:98.84%
ee:100%
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Product Introduction

Bioactivity
Description
Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.
In vivo
This study was performed in 2 groups of subjects suffering from seborrheic dermatitis. The first group (n = 17) remained untreated and was used as a control. Clinical, mycological, and metrological assessments were performed at inclusion and during the following 2 weeks. The second group of subjects (n = 10) received a single 200-mg oral dose of pramiconazole at inclusion. Clinical, mycological, and bio-metrological evaluations were performed before and during 1 month following the single antifungal intake. For both parts of the study, several parameters were assessed including yeast density, desquamation, erythema, itching, and sebum excretion. Results: In the control group, no significant changes were observed in any of the parameters during the observation period. The findings were markedly different in the pramiconazole-treated subjects. The yeast density was significantly improved on days 3, 7, and 28. Desquamation, erythema, itching, and the global clinical evaluation as assessed by the patients and investigators significantly improved on days 7 and 28. A trend in the decrease of scaliness was noted. No effect on sebum excretion was evidenced. In conclusion, a single 200-mg dose of pramiconazole exhibits in vivo efficacy in controlling some important clinical aspects of seborrheic dermatitis. Following a reduction in the number of yeasts on day 3, a decrease in the severity of clinical signs and symptoms occurred from day 7 onwards. Sebum excretion appeared uninvolved in the clearing process of seborrheic dermatitis. A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in Malassezia present on lesional skin is first decreased, followed by clearing of the clinical signs.[3]
AliasR-126638, R126638, R 126638, Azoline
Chemical Properties
Molecular Weight659.73
FormulaC35H39F2N7O4
Cas No.219923-85-0
SmilesC([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(C)C)CC5)OC1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6.25 mg/mL (9.47 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5158 mL7.5789 mL15.1577 mL75.7886 mL
5 mM0.3032 mL1.5158 mL3.0315 mL15.1577 mL

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