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Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $53 | In Stock | |
5 mg | $120 | In Stock | |
10 mg | $175 | In Stock | |
25 mg | $292 | In Stock | |
50 mg | $433 | In Stock | |
100 mg | $638 | In Stock | |
1 mL x 10 mM (in DMSO) | $117 | In Stock |
Description | Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite. |
In vivo | Proguanil (2.9 mg/kg, orally, once daily) treatment of Wistar albino rats showed mild degenerative changes at day 5 and severe degenerative changes within 6 weeks, and resulted in a significant decrease in serum testosterone levels in the rats. [4] |
Alias | Chloroguanide, Chlorguanide |
Molecular Weight | 253.73 |
Formula | C11H16ClN5 |
Cas No. | 500-92-5 |
Smiles | ClC1=CC=C(C=C1)NC(=N)NC(=N)NC(C)C |
Relative Density. | 1.29g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 40 mg/mL (157.65 mM), Sonication is recommended. DMSO: 120 mg/mL (472.94 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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