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PROTAC BRD4 Degrader-5
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Catalog No. T36242Cas No. 2409538-70-9
PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.
PROTAC BRD4 Degrader-5
😃Good
Catalog No. T36242Cas No. 2409538-70-9
PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $283 | Backorder | |
| 5 mg | $619 | Backorder | |
| 10 mg | $993 | Backorder | |
| 25 mg | $1,470 | Backorder | |
| 50 mg | $1,990 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,080 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand. |
| In vitro | 5-100 nM PROTAC BRD4 Degrader-5 treatment of MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells for 4 h was able to degrade BRD4 in the cells. [1] |
| Molecular Weight | 1016.67 |
| Formula | C50H62ClN9O8S2 |
| Cas No. | 2409538-70-9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL(118.03 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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