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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $296 | In Stock | |
2 mg | $438 | In Stock | |
5 mg | $727 | In Stock | |
10 mg | $1,160 | In Stock | |
25 mg | $1,720 | In Stock | |
50 mg | $2,290 | In Stock |
Description | PROTAC PD-1/PD-L1 degrader-1 is a PD-L1 degrading PROTAC that inhibits PD-1/PD-L1 interaction (IC50: 39.2 nM). PROTAC PD-1/PD-L1 degrader-1 restores immunity in Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model of suppressed immunity, which reduces the protein content of PD-L1 in a lysosomal-dependent manner. |
In vitro | PROTAC PD-1/PD-L1 degrader-1 (compound p22) can reduce cell surface PD-L1 expression by more than 14%; PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduced PD-L1 expression by 21% and 35% at 1 μM and 10 μM, respectively, in a dose-dependent manner. [1] |
Molecular Weight | 1076.59 |
Formula | C59H58ClN7O11 |
Cas No. | 2447066-37-5 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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