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PROTAC PD-1/PD-L1 degrader-1

🥰Excellent
Catalog No. T40112Cas No. 2447066-37-5

PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.

PROTAC PD-1/PD-L1 degrader-1

PROTAC PD-1/PD-L1 degrader-1

🥰Excellent
Purity: 99.07%
Catalog No. T40112Cas No. 2447066-37-5
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
Pack SizePriceAvailabilityQuantity
1 mg$253In Stock
5 mg$619In Stock
10 mg$987In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
100 mg$2,770In Stock
200 mg$3,730In Stock
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Purity:99.07%
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Product Introduction

Bioactivity
Description
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
In vitro
PROTAC PD-1/PD-L1 degrader-1 (compound p22) significantly reduces PD-L1 expression on the cell surface by over 14%[1]. When administered at 1-10 μM for 24 hours, it decreases PD-L1 levels dose-dependently, with reductions of 21% and 35% at 1 μM and 10 μM, respectively[1]. Western Blot Analysis in MDA-MB-231 cell lines confirmed its efficacy in modulating PD-L1 expression at these dosages[1].
Chemical Properties
Molecular Weight1076.59
FormulaC59H58ClN7O11
Cas No.2447066-37-5
SmilesN#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(Cl)C=C2CN6CCCCC6C(=O)N7CCN(C(=O)CCCC(=O)NC8=CC=CC=9C(=O)N(C(=O)C89)C%10C(=O)NC(=O)CC%10)CC7
Relative Density.1.45 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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