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Protoporphyrin IX disodium
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Catalog No. T200997Cas No. 50865-01-5
Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.
Protoporphyrin IX disodium
😃Good
Catalog No. T200997Cas No. 50865-01-5
Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma. |
| In vitro | Protoporphyrin IX disodium, when administered at a dosage of 3.6 nmol/g to tissue, causes necrosis of the normal rat colonic mucosa upon exposure to light. At a concentration of 6.6 nmol/g in rat tumors, it delays tumor growth following irradiation. Additionally, a rapid increase in nuclear G4 levels in Hela cells is observed with Protoporphyrin IX disodium at concentrations ranging from 0 to 25 μM, when applied for 2 hours. |
| In vivo | Following a single intravenous injection of aminolevulinic acid at a dosage of 300 mg/kg, the highest concentrations of Protoporphyrin IX disodium were observed in the liver and intestines of rats, approximately 3 hours post-administration, reaching about 6.3 nmol/g of tissue. This was followed by the aorta, which showed a concentration of 4.3 nmol/g of tissue, and the esophagus, which had around 2.1 nmol/g of tissue. |
| Molecular Weight | 606.62 |
| Formula | C34H32N4Na2O4 |
| Cas No. | 50865-01-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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