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Py-MAA-Val-Cit-PAB-MMAE
Catalog No. T77876Cas No. 2247398-68-9
Alias AAJ8D6-PY-Val-Cit-MMAE
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. Targeting TRAILR2, Zapadcine-3a is internalized into tumor cell lysosomes, releasing a small molecular compound that selectively eradicates TRAILR2-positive tumor cells, potentially leading to tumor remission [1].
Py-MAA-Val-Cit-PAB-MMAE
Catalog No. T77876Alias AAJ8D6-PY-Val-Cit-MMAECas No. 2247398-68-9
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. Targeting TRAILR2, Zapadcine-3a is internalized into tumor cell lysosomes, releasing a small molecular compound that selectively eradicates TRAILR2-positive tumor cells, potentially leading to tumor remission [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. Targeting TRAILR2, Zapadcine-3a is internalized into tumor cell lysosomes, releasing a small molecular compound that selectively eradicates TRAILR2-positive tumor cells, potentially leading to tumor remission [1]. |
| Alias | AAJ8D6-PY-Val-Cit-MMAE |
| Molecular Weight | 1446.79 |
| Formula | C72H111N13O16S |
| Cas No. | 2247398-68-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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