Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. By targeting TRAILR2, Zapadcine-3a is internalized into the lysosomes of tumor cells, where it subsequently releases a small molecular compound that selectively eradicates TRAILR2-positive tumor cells, potentially leading to tumor remission [1].