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RCM-1

🥰Excellent
Catalog No. T16725Cas No. 339163-65-4

RCM-1 is an inhibitor of FOXM1.

RCM-1

RCM-1

🥰Excellent
Purity: 99.89%
Catalog No. T16725Cas No. 339163-65-4
RCM-1 is an inhibitor of FOXM1.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$82In Stock
10 mg$141In Stock
25 mg$297In Stock
50 mg$491In Stock
100 mg$716In Stock
1 mL x 10 mM (in DMSO)$91In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
RCM-1 is an inhibitor of FOXM1.
In vitro
RCM-1 inhibits cellular proliferation via the increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as the growth of cancer cell colonies in vitro. Treatment with RCM-1 increases the duration of mitosis and cell cycle in the cancer cell lines [1].
In vivo
RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment reduces the growth of the human H2122 lung adenocarcinoma in mice. RCM-1 treatment reduces tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. RCM-1 treatment decreases the growth of Rd76-9 rhabdomyosarcomas in mice. The RCM-1-treated Rd76-9 tumors display reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment reduces the growth of B16-FlO melanoma tumors in mice [1].
Chemical Properties
Molecular Weight424.58
FormulaC20H12N2OS4
Cas No.339163-65-4
SmilesO=C(CSc1nc(cc(-c2cccs2)c1C#N)-c1cccs1)c1cccs1
Relative Density.1.49 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16.67 mg/mL (39.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3553 mL11.7763 mL23.5527 mL117.7634 mL
5 mM0.4711 mL2.3553 mL4.7105 mL23.5527 mL
10 mM0.2355 mL1.1776 mL2.3553 mL11.7763 mL
20 mM0.1178 mL0.5888 mL1.1776 mL5.8882 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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