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RF9 acetate

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Purity:99.35%

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COA HPLC MS

RF9 acetate

Catalog No. T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

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Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$212	In Stock
10 mg	$318	In Stock
25 mg	$573	In Stock
50 mg	$819	In Stock
100 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$283	In Stock

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Product Introduction

Bioactivity

Description	RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
In vitro	In Neuro 2A cells, Pretrement of RF9 acetate (10 μM) completely blocks NPFF induced neurite outgrowth[2].
In vivo	RF9 acetate (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked When RF9 acetate is applied in conjunction with NPFF. RF9 acetate (0.1 mg/kg, s.c. min before 0.3 mg/kg heroin or saline on basal nociceptive threshold) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[2].

Chemical Properties

Molecular Weight	542.67
Formula	C28H42N6O5
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (101.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8427 mL	9.2137 mL	18.4274 mL	92.1370 mL
5 mM	0.3685 mL	1.8427 mL	3.6855 mL	18.4274 mL
10 mM	0.1843 mL	0.9214 mL	1.8427 mL	9.2137 mL
20 mM	0.0921 mL	0.4607 mL	0.9214 mL	4.6069 mL
50 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8427 mL
100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.9214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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