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RF9 acetate
🥰Excellent
Catalog No. T16738L
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
RF9 acetate
🥰Excellent
Purity: 99.35%
Catalog No. T16738L
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $127 | In Stock | |
| 10 mg | $191 | In Stock | |
| 25 mg | $343 | In Stock | |
| 50 mg | $491 | In Stock | |
| 100 mg | $678 | In Stock | |
| 200 mg | $913 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $170 | In Stock |
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Purity:99.35%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. |
| Targets&IC50 | NPFF1 (human):58 nM (Ki), NPFF2 (human):75 nM (Ki) |
| In vitro | In Neuro 2A cells, Pretrement of RF9 acetate (10 μM) completely blocks NPFF induced neurite outgrowth[2]. |
| In vivo | RF9 acetate (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked When RF9 acetate is applied in conjunction with NPFF. RF9 acetate (0.1 mg/kg, s.c. min before 0.3 mg/kg heroin or saline on basal nociceptive threshold) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[2]. |
| Molecular Weight | 542.67 |
| Formula | C28H42N6O5 |
| Smiles | O=C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)CCC/N=C(N)\N)C(C2)(C3)CC4CC3CC2C4.CC(O)=O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (101.35 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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