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RMC-4998
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Catalog No. T79870Cas No. 2642037-07-6
RMC-4998 is a molecular glue compound with potent antitumor activity, forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C hinders the interaction between activated KRAS mutants and downstream effector proteins, obstructing proliferative cell signaling [1].
RMC-4998
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Catalog No. T79870Cas No. 2642037-07-6
RMC-4998 is a molecular glue compound with potent antitumor activity, forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C hinders the interaction between activated KRAS mutants and downstream effector proteins, obstructing proliferative cell signaling [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RMC-4998 is a molecular glue compound with potent antitumor activity, forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C hinders the interaction between activated KRAS mutants and downstream effector proteins, obstructing proliferative cell signaling [1]. |
| Molecular Weight | 983.25 |
| Formula | C57H74N8O7 |
| Cas No. | 2642037-07-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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