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S63845

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Purity:98.56%

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COA HPLC HNMR

S63845

Catalog No. T5346Cas No. 1799633-27-4

S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)

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Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$148	In Stock
10 mg	$247	In Stock
25 mg	$443	In Stock
50 mg	$653	In Stock
1 mL x 10 mM (in DMSO)	$225	In Stock

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Product Introduction

Bioactivity

Description	S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)
Targets&IC50	MCL1:0.19 nM (Kd)
In vitro	S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1].
In vivo	In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1].

Chemical Properties

Molecular Weight	829.26
Formula	C39H37ClF4N6O6S
Cas No.	1799633-27-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 33.33 mg/mL (40.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2059 mL	6.0295 mL	12.0589 mL	60.2947 mL
5 mM	0.2412 mL	1.2059 mL	2.4118 mL	12.0589 mL
10 mM	0.1206 mL	0.6029 mL	1.2059 mL	6.0295 mL
20 mM	0.0603 mL	0.3015 mL	0.6029 mL	3.0147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc