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S63845

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Catalog No. T5346Cas No. 1799633-27-4

S63845 is a selective myeloid leukemia 1(MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.

S63845

S63845

🥰Excellent
Purity: 98.56%
Catalog No. T5346Cas No. 1799633-27-4
S63845 is a selective myeloid leukemia 1(MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.
Pack SizePriceAvailabilityQuantity
1 mg$79In Stock
5 mg$148In Stock
10 mg$247In Stock
25 mg$443In Stock
50 mg$653In Stock
1 mL x 10 mM (in DMSO)$225In Stock
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Purity:98.56%
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Product Introduction

Bioactivity
Description
S63845 is a selective myeloid leukemia 1(MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.
Targets&IC50
MCL1:0.19 nM (Kd)
In vitro
METHODS: HCT-116 cells were treated with S63845 (0.001-10 μM), and the levels of MCL1 and BCL-XL proteins in the cells were analyzed by Western blot.
RESULTS S63845 effectively increased the level of MCL1 protein in the HCT-116 colon cancer cell line, but had no effect on the level of BCL-XL protein. The increase in MCL1 protein level was not accompanied by an increase in MCL1 mRNA level, but was associated with a prolonged protein half-life. [1]
In vivo
METHODS: S63845 (6.25, 12.5, 25 mg/kg, intravenous injection) was used to treat immunocompromised mice bearing human multiple myeloma (H929 and AMO1) xenografts, and its antitumor activity was observed.
RESULTS S63845 showed dose-dependent antitumor activity; the maximum tumor growth inhibition (TGImax) was 114% in the AMO1 model and 103% in the H929 model. [1]
Chemical Properties
Molecular Weight829.26
FormulaC39H37ClF4N6O6S
Cas No.1799633-27-4
SmilesCN1CCN(CCOc2ccc(-c3c(sc4ncnc(O[C@@H](Cc5ccccc5OCc5ccnn5CC(F)(F)F)C(O)=O)c34)-c3ccc(F)o3)c(C)c2Cl)CC1
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 33.33 mg/mL (40.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2059 mL6.0295 mL12.0589 mL60.2947 mL
5 mM0.2412 mL1.2059 mL2.4118 mL12.0589 mL
10 mM0.1206 mL0.6029 mL1.2059 mL6.0295 mL
20 mM0.0603 mL0.3015 mL0.6029 mL3.0147 mL

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