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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $79 | In Stock | |
5 mg | $148 | In Stock | |
10 mg | $247 | In Stock | |
25 mg | $443 | In Stock | |
50 mg | $653 | In Stock | |
1 mL x 10 mM (in DMSO) | $225 | In Stock |
Description | S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM) |
Targets&IC50 | MCL1:0.19 nM (Kd) |
In vitro | S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1]. |
In vivo | In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1]. |
Molecular Weight | 829.26 |
Formula | C39H37ClF4N6O6S |
Cas No. | 1799633-27-4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 33.33 mg/mL (40.19 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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