Shopping Cart
- Remove All
Your shopping cart is currently empty
Saroglitazar Magnesium
🥰Excellent
Catalog No. T12834Cas No. 1639792-20-3
Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).
Saroglitazar Magnesium
🥰Excellent
Purity: 98.1%
Catalog No. T12834Cas No. 1639792-20-3
Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $53 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $215 | In Stock | |
| 25 mg | $343 | In Stock | |
| 50 mg | $463 | In Stock | |
| 100 mg | $592 | In Stock | |
| 200 mg | $783 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $213 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreSelect Batch
Purity:98.1%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM). |
| Targets&IC50 | PPARγ:3 nM （EC50， HepG2 cell）, PPARα:0.65 pM （EC50， HepG2 cell） |
| In vivo | In db/db mice, Saroglitazar (0.01-3 mg/kg per day, orally) treatment with 12-day causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with highly significant (91%) reduction in serum insulin and AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose.in Wistar rats and marmosets A 90-day repeated dose comparative study confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes[1]. |
| Molecular Weight | 901.43 |
| Formula | C50H56MgN2O8S2 |
| Cas No. | 1639792-20-3 |
| Smiles | C(C)O1[Mg+2]2(O(CC)C(CC3=CC=C(OCCN4C(=CC=C4C)C5=CC=C(SC)C=C5)C=C3)C(=O)[O-]2)[O-]C(=O)C1CC6=CC=C(OCCN7C(=CC=C7C)C8=CC=C(SC)C=C8)C=C6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 112.5 mg/mL (124.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Saroglitazar Magnesium | purchase Saroglitazar Magnesium | Saroglitazar Magnesium cost | order Saroglitazar Magnesium | Saroglitazar Magnesium chemical structure | Saroglitazar Magnesium in vivo | Saroglitazar Magnesium formula | Saroglitazar Magnesium molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.