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SB 203580 hydrochloride
🥰Excellent
Catalog No. T21675Cas No. 869185-85-3
Alias SB203580 hydrochloride, RWJ64809 hydrochloride, RWJ 64809 hydrochloride, Adezmapimod hydrochloride
SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.
SB 203580 hydrochloride
🥰Excellent
Catalog No. T21675Alias SB203580 hydrochloride, RWJ64809 hydrochloride, RWJ 64809 hydrochloride, Adezmapimod hydrochlorideCas No. 869185-85-3
SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $36 | In Stock | |
| 10 mg | $54 | In Stock | |
| 25 mg | $85 | In Stock | |
| 50 mg | $123 | In Stock | |
| 100 mg | $180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain. |
| Targets&IC50 | PKB:5 μM, SAPK2a/p38:50 nM, SAPK2b/p38β2:500 nM |
| In vitro | SB 203580 hydrochloride is a selective ATP-competitive p38 MAPK inhibitor against SAPK2a/p38 IC50=50 nM and SAPK2b/p38β2 IC50=500 nM. [1] 0-30 μM SB 203580 hydrochloride pre-incubation, 1 hr and incubation in the presence of 20 ng/mL IL-2 for 24 hr was able to inhibit the IL-2-induced proliferation of primary human T cells, mouse CT6 T cells, or BAF F7 B cells with IC50 values of 3-5 μM. [2] SB 203580 hydrochloride blocks the phosphorylation of PKB (protein kinase B) with an IC50 of approximately 5 μM. [2] |
| In vivo | An exogenous tumor model in female thymus-free Nu/Nu mice, 5 mg/kg/day SB 203580 hydrochloride, was injected intraperitoneally daily for 16 consecutive days, and the tumors in the p38WT group were significantly smaller than those in the p38TM tumors of the parallel treatments after treatment. [3] |
| Alias | SB203580 hydrochloride, RWJ64809 hydrochloride, RWJ 64809 hydrochloride, Adezmapimod hydrochloride |
| Molecular Weight | 413.9 |
| Formula | C21H17ClFN3OS |
| Cas No. | 869185-85-3 |
| Smiles | Cl.O=S(C=1C=CC(=CC1)C2=NC(C=3C=CN=CC3)=C(N2)C=4C=CC(F)=CC4)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL(4.83 mM), Sonication is recommended. DMSO: 80 mg/mL(193.28 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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