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SD-1029
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Catalog No. T24774Cas No. 118372-34-2
Alias SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488
SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.
SD-1029
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Catalog No. T24774Alias SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488Cas No. 118372-34-2
SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $85 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling. |
| In vitro | SD-1029 inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells and suppresses p-Stat3 levels in human breast and ovarian cancer cell lines including cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells. [1] SD-1029 inhibits JAK2 phosphorylation and the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression. [2] |
| Alias | SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488 |
| Molecular Weight | 639.25 |
| Formula | C25H32Br2Cl2N2O3 |
| Cas No. | 118372-34-2 |
| Smiles | O=C1C2=C(CCC1CN(C)C)OC3=C(C2C4=CC=C(C(Cl)=C4)Cl)C(C(CC3)CN(C)C)=O.Br.Br |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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