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Simotinib

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Purity:99.7%

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COA HNMR HPLC MS

Simotinib

Catalog No. T35916Cas No. 944258-89-3

Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer.

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Pack Size	Price	Availability	Quantity
1 mg	$199	In Stock

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Product Introduction

Bioactivity

Description	Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer.
Targets&IC50	EGFR:19.9 nM
In vitro	In vitro studies have shown that sunitinib inhibits the growth of EGFR and EGFR-overexpressing human A431 tumor cells in a dose-dependent manner, with no significant activity against other kinases examined in the study[1].
In vivo	Multiple doses of sunitinib reduced rat body weight by decreasing food intake, similar to human patients, indicating adverse effects of sunitinib on the gastrointestinal tract[2].
Alias	AL-6802, SIM-6802

Chemical Properties

Molecular Weight	500.95
Formula	C25H26ClFN4O4
Cas No.	944258-89-3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mg/mL (199.60 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9962 mL	9.9810 mL	19.9621 mL	99.8104 mL
5 mM	0.3992 mL	1.9962 mL	3.9924 mL	19.9621 mL
10 mM	0.1996 mL	0.9981 mL	1.9962 mL	9.9810 mL
20 mM	0.0998 mL	0.4991 mL	0.9981 mL	4.9905 mL
50 mM	0.0399 mL	0.1996 mL	0.3992 mL	1.9962 mL
100 mM	0.0200 mL	0.0998 mL	0.1996 mL	0.9981 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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