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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $199 | In Stock |
Description | Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer. |
Targets&IC50 | EGFR:19.9 nM |
In vitro | In vitro studies have shown that sunitinib inhibits the growth of EGFR and EGFR-overexpressing human A431 tumor cells in a dose-dependent manner, with no significant activity against other kinases examined in the study[1]. |
In vivo | Multiple doses of sunitinib reduced rat body weight by decreasing food intake, similar to human patients, indicating adverse effects of sunitinib on the gastrointestinal tract[2]. |
Alias | AL-6802, SIM-6802 |
Molecular Weight | 500.95 |
Formula | C25H26ClFN4O4 |
Cas No. | 944258-89-3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (199.60 mM), when pH is adjusted to 3 with HCl. Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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