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Sinbaglustat

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Purity:99.93%

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COA HNMR LCMS HPLC

Sinbaglustat

Catalog No. T40542Cas No. 441061-33-2

Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain barrier.Sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of central neurodegenerative disorders associated with lysosomal dysfunction. Sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of lysosomal dysfunction-related central neurodegenerative diseases.

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Pack Size	Price	Availability
1 mg	$157	In Stock
5 mg	$397	In Stock
10 mg	$595	In Stock
25 mg	$949	In Stock
50 mg	$1,290	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$360	In Stock

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Product Introduction

Bioactivity

Description	Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain barrier.Sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of central neurodegenerative disorders associated with lysosomal dysfunction. Sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of lysosomal dysfunction-related central neurodegenerative diseases.
In vitro	Sinbaglustat (OGT2378) (20 μM) leads to a remarkable reduction in the synthesis of glucosylceramide by 93% and ganglioside by >95% when compared to untreated MEB4 cells. This reduction occurs without inducing any cytotoxicity or antiproliferative effects.[1] Sinbaglustat is 50-fold more potent in inhibiting GBA2 than GCS.[2]
In vivo	Sinbaglustat (OGT2378) (2500 mg/kg/day; p.o.; in the powdered chow; corresponding to 35-40 mg/mouse/day of Sinbaglustat; Female syngeneic C57BL/6 mice and bearing MEB4 melanoma tumor, 6-8 weeks old bearing MEB4 melanoma tumor) is highly effective in impeding melanoma tumor growth in vivo. The effectiveness of p.o. Sinbaglustat in this murine model suggests that inhibition of glycosphingolipid synthesis is a promising approach to inhibit tumor progression.[1]
Alias	ACT-519276, Sinbaglustat, OGT2378

Chemical Properties

Molecular Weight	233.3
Formula	C11H23NO4
Cas No.	441061-33-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46.66 mg/mL (200 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2863 mL	21.4316 mL	42.8633 mL	214.3163 mL
5 mM	0.8573 mL	4.2863 mL	8.5727 mL	42.8633 mL
10 mM	0.4286 mL	2.1432 mL	4.2863 mL	21.4316 mL
20 mM	0.2143 mL	1.0716 mL	2.1432 mL	10.7158 mL
50 mM	0.0857 mL	0.4286 mL	0.8573 mL	4.2863 mL
100 mM	0.0429 mL	0.2143 mL	0.4286 mL	2.1432 mL

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