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SJF 1521

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SJF 1521

Catalog No. T36244Cas No. 2230821-40-4

Selective EGFR Degrader. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

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Pack Size	Price	Availability	Quantity
5 mg	$987	35 days

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Product Introduction

Bioactivity

Description

Selective EGFR Degrader. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

Chemical Properties

Molecular Weight	1074.66
Formula	C57H61ClFN7O9S
Cas No.	2230821-40-4

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 107.47 mg/mL(100 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9305 mL	4.6526 mL	9.3053 mL	46.5263 mL
5 mM	0.1861 mL	0.9305 mL	1.8611 mL	9.3053 mL
10 mM	0.0931 mL	0.4653 mL	0.9305 mL	4.6526 mL
20 mM	0.0465 mL	0.2326 mL	0.4653 mL	2.3263 mL
50 mM	0.0186 mL	0.0931 mL	0.1861 mL	0.9305 mL
100 mM	0.0093 mL	0.0465 mL	0.0931 mL	0.4653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc