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SKI2852
🥰Excellent
Catalog No. T28796Cas No. 1346554-47-9
Alias SKI-2852
SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models.
SKI2852
🥰Excellent
Catalog No. T28796Alias SKI-2852Cas No. 1346554-47-9
SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $55 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $208 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models. |
| Targets&IC50 | HSD1 (human):2.9 nM, HSD1 (Ms):1.6 nM |
| In vitro | SKI2852, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), has IC 50 values of 2.9 nM and 1.6 nM for HEK293 cells transfected with human (h11βHSD1) and mouse 11βHSD1 (m11βHSD1), respectively. [1] |
| In vivo | Oral treatment with SKI2852 (12.5 mg/kg) significantly reduced weight gain in severely obese ob/ob mice. Results of SKI2852 (1, 3 or 10 mg/kg once daily for 8.5 weeks, administered orally) showed that all doses of SKI2852 significantly reduced FFA levels. Inhibition of 11βHSD1 by SKI2852 (12.5 mg/kg) may improve systemic and hepatic insulin sensitivity and reverse diabetic symptoms by at least partially inhibiting these gluconeogenic enzyme expression levels in DIO mice. [1] |
| Alias | SKI-2852 |
| Molecular Weight | 543.65 |
| Formula | C27H34FN5O4S |
| Cas No. | 1346554-47-9 |
| Smiles | N(C(=O)C1=NC(=NC=C1)N2[C@H](C)CN(CC2)C3=C(F)C=C(S(C)(=O)=O)C=C3)[C@@H]4[C@]5(CC6(O)C[C@@]4(CC(C5)C6)[H])[H] |
| Relative Density. | 1.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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