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SQ-31765
Contact us for more batch information
SQ-31765
Catalog No. T12993Cas No. 138383-07-0
SQ-31765 is a blocker of benzazepine calcium channel.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SQ-31765 is a blocker of benzazepine calcium channel. |
| In vivo | SQ-31765 (SQ 31,765) effectively mitigates the severity of ischemia independent of myocardial blood flow or hemodynamic changes. In a study, anesthetized dogs were administered either saline (n=6), SQ-31765 (n=6; 0.2 mg/kg), or SQ 32,189 (n=6; 0.2 mg/kg) intravenously 10 minutes prior to inducing ischemia. The research focused on the compound's impact on pacing-induced ST-segment elevation and myocardial blood flow during left anterior descending coronary artery stenosis. SQ-31765 significantly lowered ST-segment elevation (P<0.05) at 10, 40, and 70 minutes post-infusion, showcasing a notable reduction (5.9±1.4 mV at 70 minutes) compared to the saline group (12.0±1.4 mV at 70 minutes). All test groups exhibited a marked decrease in subendocardial flow due to left anterior descending coronary artery stenosis during atrial pacing prior to drug administration, underscoring SQ-31765's protective effects against pacing-induced myocardial injury. |
| Molecular Weight | 464.48 |
| Formula | C24H27F3N2O4 |
| Cas No. | 138383-07-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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