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SSTC3

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Purity:98.65%

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COA LCMS

SSTC3

Catalog No. T13004Cas No. 1242422-09-8

SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd of 32 nM.

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Pack Size	Price	Availability	Quantity
1 mg	$149	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

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Product Introduction

Bioactivity

Description	SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd of 32 nM.
In vitro	In colorectal cancer (CRC) cell lines, the results of SSTC3 (0-1 μM; 5 days) indicate that SSTC3 decreased cell viability[1].
In vivo	In five-week-old Apcmin mice, SSTC3 (10 mg/kg; intraperitoneal injection, for 1 month) inhibited the growth of tumors driven by Apc mutation[1].

Chemical Properties

Molecular Weight	518.53
Formula	C23H17F3N4O3S2
Cas No.	1242422-09-8

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (192.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9285 mL	9.6426 mL	19.2853 mL	96.4264 mL
5 mM	0.3857 mL	1.9285 mL	3.8571 mL	19.2853 mL
10 mM	0.1929 mL	0.9643 mL	1.9285 mL	9.6426 mL
20 mM	0.0964 mL	0.4821 mL	0.9643 mL	4.8213 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9285 mL
100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.9643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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