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T-448

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T-448

Catalog No. T13057Cas No. 1597426-53-3

T-448 is an orally available and potent lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.

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Pack Size	Price	Availability
1 mg	$786	In Stock
5 mg	$1,387	In Stock
10 mg	$1,999	In Stock

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Product Introduction

Bioactivity

Description	T-448 is an orally available and potent lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.
In vitro	In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1].
In vivo	In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1].
Alias	T 448, T448

Chemical Properties

Molecular Weight	386.47
Formula	C19H22N4O3S
Cas No.	1597426-53-3

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16 mg/mL (41.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5875 mL	12.9376 mL	25.8752 mL	129.3761 mL
5 mM	0.5175 mL	2.5875 mL	5.1750 mL	25.8752 mL
10 mM	0.2588 mL	1.2938 mL	2.5875 mL	12.9376 mL
20 mM	0.1294 mL	0.6469 mL	1.2938 mL	6.4688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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