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T-448
Catalog No. T13057Cas No. 1597426-53-3
Alias T448, T 448
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
T-448
Catalog No. T13057Alias T448, T 448Cas No. 1597426-53-3
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $455 | In Stock | |
| 5 mg | $1,050 | In Stock | |
| 10 mg | $1,420 | In Stock | |
| 25 mg | $2,090 | In Stock | |
| 50 mg | $2,850 | In Stock | |
| 100 mg | $3,830 | In Stock | |
| 200 mg | $5,180 | In Stock |
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Purity:98.63%
ee:97.7%
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Product Introduction
Bioactivity
Chemical Properties
| Description | T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM. |
| Targets&IC50 | LSD1:22 nM, LSD1:22 nM |
| In vitro | In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1]. |
| In vivo | In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1]. |
| Alias | T448, T 448 |
| Molecular Weight | 386.47 |
| Formula | C19H22N4O3S |
| Cas No. | 1597426-53-3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (41.40 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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