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T-448

🥰Excellent
Catalog No. T13057Cas No. 1597426-53-3
Alias T448, T 448

T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.

T-448

T-448

🥰Excellent
Purity: 98.63%
Catalog No. T13057Alias T448, T 448Cas No. 1597426-53-3
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
Pack SizePriceAvailabilityQuantity
1 mg$455In Stock
5 mg$1,050In Stock
10 mg$1,420In Stock
25 mg$2,090In Stock
50 mg$2,850In Stock
100 mg$3,830In Stock
200 mg$5,180In Stock
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Purity:98.63%
ee:97.7%
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Product Introduction

Bioactivity
Description
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
Targets&IC50
LSD1:22 nM , LSD1:22 nM
In vitro
In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1].
In vivo
In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1].
AliasT448, T 448
Chemical Properties
Molecular Weight386.47
FormulaC19H22N4O3S
Cas No.1597426-53-3
SmilesC(=C/C(O)=O)\C(O)=O.N([C@H]1[C@@H](C1)C2=CC(C(NC3=NN=C(C)S3)=O)=CC=C2)C4CCC4
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16 mg/mL (41.40 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5875 mL12.9376 mL25.8752 mL129.3761 mL
5 mM0.5175 mL2.5875 mL5.1750 mL25.8752 mL
10 mM0.2588 mL1.2938 mL2.5875 mL12.9376 mL
20 mM0.1294 mL0.6469 mL1.2938 mL6.4688 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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