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Tankyrase-IN-2

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Catalog No. T13078Cas No. 1588870-36-3

Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively

Tankyrase-IN-2

Tankyrase-IN-2

😃Good
Catalog No. T13078Cas No. 1588870-36-3
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
Pack SizePriceAvailabilityQuantity
25 mg$1,4006-8 weeks
50 mg$1,8206-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
Targets&IC50
TNKS2:7 nM , PARP1:710 nM , TNKS1:10 nM
In vitro
In DLD1 cells, Tankyrase-IN-2 (1-10000 nM; 24 hours) leads to a dose-dependent increase of tankyrase protein abundance (EC50 of 320 nM). This is in the same potency range as the value for axin2 increase with EC50 of 319 nM.
Chemical Properties
Molecular Weight316.3
FormulaC17H14F2N2O2
Cas No.1588870-36-3
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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