Shopping Cart
- Remove All
![TargetMol](https://newstatic.targetmol.com/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
2 mg | $169 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $892 | In Stock | |
50 mg | $1,450 | In Stock | |
100 mg | $1,970 | In Stock |
Description | TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune tolerance in tumor tissues. |
In vitro | TDO-IN-1 (HT-28) demonstrates a significant tumoricidal effect on different tumor lines when treated at concentrations ranging from 0 to 100 μM for 24 hours. The IC50 values for various tumor cell lines are as follows: 0.54 μM (HepG2), 5.08 μM (Hepa1-6), 1.34 μM (H22), 37.39 μM (B16), 3.43 μM (MOLM-13), and 7.25 μM (Jurkat)[1].Moreover, TDO-IN-1 (0-100 μM; 24 h) exhibits minimal cytotoxic activity against normal cells (HEK 293 cells) when the concentration is below 10 μM[1]. |
In vivo | Administered orally at a dose of 25 mg/kg once daily for 9 days, TDO-IN-1 (HT-28) enhances the efficacy of tumor immunotherapy in CT26 tumors expressing TDO. This treatment substantially inhibits the proliferation of CT26 tumors in mice[1]. |
Molecular Weight | 350.3 |
Formula | C16H13F3N4O2 |
Cas No. | 2490672-92-7 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (171.28 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.