Thanatin acetate

Name: Thanatin acetate
Brand: TargetMol
SKU: T80999L
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T80999L

Alias Thanatin acetate(214542-43-5 Free base)

Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting the growth of bacteria and fungi by targeting the LptC-LptA interaction and destabilizing the LptA complex involved in lipopolysaccharide transport.

Thanatin acetate

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Catalog No. T80999LAlias Thanatin acetate(214542-43-5 Free base)

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$172	In Stock
10 mg	$286	In Stock
25 mg	$483	In Stock
50 mg	$693	In Stock
100 mg	$962	In Stock

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Product Introduction

Bioactivity

Description	Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting the growth of bacteria and fungi by targeting the LptC-LptA interaction and destabilizing the LptA complex involved in lipopolysaccharide transport.
Targets&IC50	LptA:16 nM(Kd), LptD:39 nM(Kd)
In vitro	Thanatin acetate binds to two Lpt proteins with high affinity, and the Kd values of LptA and LptD are 16 nM and 39 nM, respectively. Thanatin acetate (70 μM) did not change the membrane permeability of bacteria. [1]
In vivo	Thanatin acetate (1, 3, 6 mg/kg, intraperitoneally administered) protects mice infected with NDM-1-produced E. coli. [2]
Alias	Thanatin acetate(214542-43-5 Free base)

Chemical Properties

Molecular Weight	2493.97
Formula	C₁₀₅H₁₈₁N₃₅O₂₉S₃
Smiles	NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCSC)=O)=O)=O)=O)CCCCN)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc