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TMN355

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Purity:99.01%

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COA HNMR HPLC

TMN355

Catalog No. T13171Cas No. 1186372-20-2

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis.

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Pack Size	Price	Availability
1 mg	$35	In Stock
2 mg	$50	In Stock
5 mg	$81	In Stock
10 mg	$123	In Stock
25 mg	$247	In Stock
50 mg	$372	In Stock
100 mg	$548	In Stock
500 mg	$1,170	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis.

In vitro

Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001). Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM).

Chemical Properties

Molecular Weight	380.8
Formula	C21H14ClFN2O2
Cas No.	1186372-20-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (105.04 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6261 mL	13.1303 mL	26.2605 mL	131.3025 mL
5 mM	0.5252 mL	2.6261 mL	5.2521 mL	26.2605 mL
10 mM	0.2626 mL	1.3130 mL	2.6261 mL	13.1303 mL
20 mM	0.1313 mL	0.6565 mL	1.3130 mL	6.5651 mL
50 mM	0.0525 mL	0.2626 mL	0.5252 mL	2.6261 mL
100 mM	0.0263 mL	0.1313 mL	0.2626 mL	1.3130 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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