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Tocilizumab
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Catalog No. T9911Cas No. 375823-41-9
Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19.
Tocilizumab
😃Good
Purity: 99.50%
Catalog No. T9911Cas No. 375823-41-9
Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $223 | In Stock | |
| 2 mg | $328 | Backorder | |
| 5 mg | $557 | In Stock | |
| 10 mg | $812 | Backorder | |
| 25 mg | $1,230 | Backorder | |
| 50 mg | $1,670 | Backorder | |
| 100 mg | $2,260 | Backorder |
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CitedSelect Batch
Concentration:20.1 mg/mL
Purity:99.50%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19. |
| In vitro | METHODS: Tocilizumab (Anti-Human IL6R) (0.001–10,000 μg/ml) was used to culture Ba/F3-gp130-hIL-6R or Ba/F3-gp130-mIL-6R cells for 2 days, and cell proliferation was observed. RESULTS Tocilizumab (Anti-Human IL6R) could inhibit cell proliferation, with an IC50 value of 13.5 ng/mL. [1] |
| In vivo | METHODS: HARA-B cells were inoculated into the left ventricle of nude mouse hearts. Three weeks after inoculation, Tocilizumab (Anti-Human IL6R) was intravenously injected weekly for the next three weeks (1.0 mg/100 μL, once every two weeks for three weeks). RESULTS The volume of each metastatic lesion in the brains of mice injected with Tocilizumab (Anti-Human IL6R) was significantly smaller. [2] |
| Cell Research | Objective: To validate that IL-6 signaling is essential for TAM (tumor-associated macrophages)-enhanced CSC (cancer stem cells) function. Concentrations: 5 μg/ml. Incubation Time: 72 h. Method: For co-culture experiments, 12-well Transwell chambers were used with 2×105 HepG2 or Hep3B cells seeded in the lower chamber one day before co-culture and either 5×105 or 1×106 TAMs added in the upper chamber. Tocilizumab or human IgG antibody were added in indicated experiments to selected wells. After 24 to 72 hours, HCC cells and CD14+ TAM cells were collected separately for analysis. Cells:HepG2 cell lines, TAMs isolated from HCCs (hepatocellular carcinoma) |
| Molecular Weight | 148 kDa |
| Cas No. | 375823-41-9 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. |
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