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Totarol

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Purity:99.46%

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COA HNMR HPLC

Totarol

Catalog No. TN2279Cas No. 511-15-9

Totarol ((+)-Totarol) shows antibacterial effects against several pathogenic Gram-positive bacteria, mycobacterium tuberculosis.

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Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$63	In Stock
50 mg	$92	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	Totarol ((+)-Totarol) shows antibacterial effects against several pathogenic Gram-positive bacteria, mycobacterium tuberculosis.
In vitro	Totarol (2 μM) inhibits the proliferation of Bacillus subtilis cells and strongly induces the filamentation in B. subtilis cells. Totarol (1.5 μM) reduces the frequency of the Z-ring occurrence per micrometer of the bacterial cell length but did not affect the nucleoid frequency, suggesting that it blocks cytokinesis by inhibiting the formation of the Z-ring. Totarol perturbs the assembly dynamics of FtsZ protofilaments in the Z-ring[1].
Alias	(+)-Totarol

Chemical Properties

Molecular Weight	286.45
Formula	C20H30O
Cas No.	511-15-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (192.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4910 mL	17.4551 mL	34.9101 mL	174.5505 mL
5 mM	0.6982 mL	3.4910 mL	6.9820 mL	34.9101 mL
10 mM	0.3491 mL	1.7455 mL	3.4910 mL	17.4551 mL
20 mM	0.1746 mL	0.8728 mL	1.7455 mL	8.7275 mL
50 mM	0.0698 mL	0.3491 mL	0.6982 mL	3.4910 mL
100 mM	0.0349 mL	0.1746 mL	0.3491 mL	1.7455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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