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Tovinontrine
🥰Excellent
Catalog No. T61833Cas No. 2062661-53-2
Alias IMR-687
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits high efficacy, with IC 50 values of 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively [1].
Tovinontrine
🥰Excellent
Purity: 98.14%
Catalog No. T61833Alias IMR-687Cas No. 2062661-53-2
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits high efficacy, with IC 50 values of 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $106 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $378 | In Stock | |
| 25 mg | $612 | In Stock | |
| 50 mg | $818 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $288 | In Stock |
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CitedSelect Batch
Purity:98.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits high efficacy, with IC 50 values of 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively [1]. |
| Targets&IC50 | PDE1A3:88.4 μM, PDE1B:8.48 μM, PDE5A2:81.9 μM, PDE9A2:9.99 nM, PDE1C:12.2 μM, PDE9A1:8.19 nM |
| In vitro | Tovinontrine (IMR-687) (0.03-10 μM) treatment for 6 hours in erythroid K562 cells increases cGMP in a dose-dependent manner.[1] IMR-687 (0.1-10 μM) treatment in erythroid K562 cells for 72 hours induces hemoglobin (HbF) in a dose-dependent manner.[1] |
| In vivo | Tovinontrine (IMR-687) (30 mg/kg/day; 30 days) resulted in a more than three-fold increase in the proportion of HbF+ F-cells (8.4% in the vehicle-treated group and 27.3% in the IMR-687 treated group), accompanied by a corresponding two-fold reduction in sickled red blood cells (56.3% in the vehicle-treated group and 24.4% in the IMR-687 treated group).[1] |
| Alias | IMR-687 |
| Molecular Weight | 394.47 |
| Formula | C21H26N6O2 |
| Cas No. | 2062661-53-2 |
| Smiles | C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(ncc2c(=O)[nH]1)C1CCOCC1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (228.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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