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U-46619
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Catalog No. T17189Cas No. 56985-40-1
Alias 9,11-Methanoepoxy PGH2
U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion.
U-46619
😃Good
Catalog No. T17189Alias 9,11-Methanoepoxy PGH2Cas No. 56985-40-1
U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $243 | 35 days | |
| 5 mg | $1,090 | 35 days | |
| 10 mg | $1,820 | 35 days |
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Concentration:10.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. |
| In vitro | U-46619 (5 μg/kg; i.v.) significantly increased blood pressure in male spontaneously hypertensive rats.[3] The effect of Esmolol on blood pressure in male spontaneously hypertensive rats was shown in the study. [3] |
| In vivo | U-46619 (5 μg/kg; i.v.) significantly increased blood pressure in male spontaneously hypertensive rats.[3] The effect of Esmolol on blood pressure in male spontaneously hypertensive rats was shown in the study. [3] |
| Alias | 9,11-Methanoepoxy PGH2 |
| Molecular Weight | 350.49 |
| Formula | C21H34O4 |
| Cas No. | 56985-40-1 |
| Smiles | C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@]2(C[C@@]1(CO2)[H])[H] |
| Relative Density. | 1.092g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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