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UC-112

🥰Excellent
Catalog No. T17195Cas No. 383392-66-3

UC-112 is a novel, potent IAP inhibitor that effectively inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).

UC-112

UC-112

🥰Excellent
Purity: 98.22%
Catalog No. T17195Cas No. 383392-66-3
UC-112 is a novel, potent IAP inhibitor that effectively inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).
Pack SizePriceAvailabilityQuantity
1 mg28 €In Stock
2 mg37 €In Stock
5 mg63 €In Stock
10 mg100 €In Stock
25 mg213 €In Stock
50 mg328 €In Stock
100 mg470 €In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)71 €In Stock
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Purity:98.22%
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Product Introduction

Bioactivity
Description
UC-112 is a novel, potent IAP inhibitor that effectively inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).
In vitro
UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112[1].
In vivo
UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].
Chemical Properties
Molecular Weight348.44
FormulaC22H24N2O2
Cas No.383392-66-3
SmilesOc1c(CN2CCCC2)cc(COCc2ccccc2)c2cccnc12
Relative Density.1.228 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 8 mg/mL (22.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8699 mL14.3497 mL28.6993 mL143.4967 mL
5 mM0.5740 mL2.8699 mL5.7399 mL28.6993 mL
10 mM0.2870 mL1.4350 mL2.8699 mL14.3497 mL
20 mM0.1435 mL0.7175 mL1.4350 mL7.1748 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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