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UC-112

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Purity:98.22%

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COA HNMR HPLC

UC-112

Catalog No. T17195Cas No. 383392-66-3

UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$39	In Stock
5 mg	$67	In Stock
10 mg	$106	In Stock
25 mg	$225	In Stock
50 mg	$346	In Stock
100 mg	$495	In Stock
500 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Product Introduction

Bioactivity

Description	UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).
In vitro	UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112[1].
In vivo	UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].

Chemical Properties

Molecular Weight	348.44
Formula	C22H24N2O2
Cas No.	383392-66-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (22.96 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3497 mL	28.6993 mL	143.4967 mL
5 mM	0.5740 mL	2.8699 mL	5.7399 mL	28.6993 mL
10 mM	0.2870 mL	1.4350 mL	2.8699 mL	14.3497 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1748 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc