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Vardenafil dihydrochloride

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Catalog No. T4480Cas No. 224789-15-5
Alias Vardenafil Hydrochloride, Levitra

Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

Vardenafil dihydrochloride

Vardenafil dihydrochloride

😃Good
Catalog No. T4480Alias Vardenafil Hydrochloride, LevitraCas No. 224789-15-5
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
Pack SizePriceAvailabilityQuantity
25 mg$46Backorder
50 mg$84Backorder
100 mg$153Backorder
200 mg$270Backorder
1 mL x 10 mM (in DMSO)$81Backorder
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Product Introduction

Bioactivity
Description
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
Targets&IC50
PDE5:0.7 nM (Cell-free), PDE1:180 nM (Cell-free)
In vitro
Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.
In vivo
Vardenafil dose-dependently potentiates erectile responses to intravenously administered sodium nitroprusside in rabbit. Vardenafil (3 mg/kg, p.o.) results in an improved object discrimination performance in rats. Vardenafil (30 mg/L, p.o.) increases both iNOS and proliferating cell nuclear antigen expression (SM cell replication) in rats, with normalization of the dynamic infusion cavernosometry drop rate and SM/collagen ratio. Vardenafil induces powerful preconditioning-like cardioprotective effect against ischemia/reperfusion injury through the opening of mitochondrial K(ATP) channels in the heart of rabbit. Vardenafil protects the ischemic myocardium against reperfusion injury through a mechanism dependent on mitochondrial K(ATP) channel opening.
AliasVardenafil Hydrochloride, Levitra
Chemical Properties
Molecular Weight561.52
FormulaC23H34Cl2N6O4S
Cas No.224789-15-5
SmilesCl.Cl.CCCc1nc(C)c2n1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mg/mL (17.27 mM)
Ethanol: 16 mg/mL (27.6 mM)
DMSO: 93 mg/mL (160.6 mM)
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.7809 mL8.9044 mL17.8088 mL89.0440 mL
5 mM0.3562 mL1.7809 mL3.5618 mL17.8088 mL
10 mM0.1781 mL0.8904 mL1.7809 mL8.9044 mL
Ethanol/DMSO
1mg5mg10mg50mg
20 mM0.0890 mL0.4452 mL0.8904 mL4.4522 mL
DMSO
1mg5mg10mg50mg
50 mM0.0356 mL0.1781 mL0.3562 mL1.7809 mL
100 mM0.0178 mL0.0890 mL0.1781 mL0.8904 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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