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Vonoprazan fumarate
🥰Excellent
Catalog No. T2404Cas No. 1260141-27-2
Alias TAK-438
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.
Vonoprazan fumarate
🥰Excellent
Purity: 100%
Catalog No. T2404Alias TAK-438Cas No. 1260141-27-2
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $40 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
| Targets&IC50 | H+, K+-ATPase:19 nM |
| In vitro | TAK-438 has demonstrated effective and sustained inhibition of gastric acid secretion stimulated by histamine in both rats and dogs. This compound exhibits notable antisecretory activity through its high accumulation in gastric tissue and low clearance rate. Unlike PPIs (Proton Pump Inhibitors), TAK-438's efficacy is not influenced by the state of gastric secretion. It inhibits basal gastric acid secretion in a dose-dependent manner, with an ID50 value of 1.26 mg/kg. Intravenous administration of TAK-438 increases the pH of gastric perfusate in a dose-dependent way, maintaining the rise in pH for up to five hours. When treated with 1 mg/kg of TAK-438, the pH value reached a stable state after 90 minutes, with a maximum pH of 5.9. |
| In vivo | TAK-438 inhibits the activity of gastric H+,K+-ATPase in a concentration-dependent manner. Its inhibitory effect remains almost unchanged under neutral (pH 7.5) and slightly acidic conditions (pH 6.5). Even at concentrations 500 times higher than its IC50 for gastric H+,K+-ATPase activity, TAK-438 does not inhibit Na+,K+-ATPase activity. TAK-438 inhibits gastric H+,K+-ATPase competitively with potassium (K+), with an inhibition constant (Ki) of 3 nM. |
| Alias | TAK-438 |
| Molecular Weight | 461.46 |
| Formula | C17H16FN3O2S·C4H4O4 |
| Cas No. | 1260141-27-2 |
| Smiles | CNCc1cn(c(c1)c1ccccc1F)S(=O)(=O)c1cnccc1.C(=C\C(=O)O)/C(=O)O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 16.67 mg/mL (36.12 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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