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VU0422288
🥰Excellent
Catalog No. T29135Cas No. 1630936-95-6
Alias VU-0422288, VU 0422288, ML-396, ML396, ML 396
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT).
VU0422288
🥰Excellent
Purity: 95.48%
Catalog No. T29135Alias VU-0422288, VU 0422288, ML-396, ML396, ML 396Cas No. 1630936-95-6
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $73 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $247 | In Stock | |
| 50 mg | $396 | In Stock | |
| 100 mg | $645 | In Stock | |
| 500 mg | $1,330 | In Stock |
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Purity:95.48%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT). |
| Targets&IC50 | mGluR7:146 nM (EC50), mGluR8:128 nM (EC50), mGluR4:108 nM (EC50) |
| In vitro | In coronal slices containing the hippocampus, VU0422288 (1 μM; 5 minutes) enhances the reduction in slope of the field excitatory postsynaptic potentials (fEPSPs) induced by 30 μM LSP4-2022[1].However, when administered alone for 10 minutes at a concentration of 1 μM, VU0422288 does not alter the slope of fEPSP, indicating that under stimulation conditions, mGlu7 does not possess reinforcing activity in Mecp2-/y slices[1]. |
| In vivo | In Mecp2+/- mice, VU0422288 (30 mg/kg; intraperitoneal injection; once daily for 17 days) rescues synaptic plasticity deficits and learning-memory phenotypes, reduces the frequency of respiratory pause, while showing no effect in Mecp2+/+ animals[1]. A single dose of VU0422288 (10 mg/kg; intraperitoneal injection) in adult male Sprague-Dawley rats exhibits a plasma/brain partition coefficient of 1.67, predicting a free brain concentration of approximately 40 nM[1]. |
| Alias | VU-0422288, VU 0422288, ML-396, ML396, ML 396 |
| Molecular Weight | 360.19 |
| Formula | C17H11Cl2N3O2 |
| Cas No. | 1630936-95-6 |
| Smiles | Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1 |
| Relative Density. | 1.445 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.6 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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