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(S)-3-Hydroxyphenylglycine

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Catalog No. T23291Cas No. 71301-82-1

(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).

(S)-3-Hydroxyphenylglycine

(S)-3-Hydroxyphenylglycine

🥰Excellent
Purity: 99.18%
Catalog No. T23291Cas No. 71301-82-1
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
Pack SizePriceAvailabilityQuantity
1 mg$77In Stock
2 mg$98In Stock
5 mg$158In Stock
10 mg$225In Stock
25 mg$377In Stock
50 mg$539In Stock
100 mg$738In Stock
200 mg$993In Stock
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Purity:99.18%
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Product Introduction

Bioactivity
Description
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
In vitro
Hippocampal neurons in the slice preparation exhibit spontaneous synchronized bursting activity in the presence of picrotoxin, a γ-aminobutyric acid-A receptor antagonist. These synchronized bursts rarely exceed 500 ms in duration and thus resemble interictal discharges. Control shows one such synchronized burst, which typically consisted of an initial abrupt discharge 100–200 ms in duration (primary burst) followed by a series of briefer phasic discharges (secondary bursts). Addition of (S)-3-hydroxyphenylglycine (250–500 μM) significantly prolonged the synchronized burst duration, primarily via a marked increase in the number of secondary bursts. These prolonged discharges ranged from 1 to 7 s in duration (4,282 ± 1,060 ms, a 1,021?± 247% increase, n = 7), and the secondary bursts within each discharge gradually changed in amplitude and frequency[2].
Chemical Properties
Molecular Weight167.16
FormulaC8H9NO3
Cas No.71301-82-1
SmilesN[C@H](C(O)=O)c1cccc(O)c1
Relative Density.1.396 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: < 1 mg/mL (insoluble)
H2O: 6.56 mg/mL (39.24 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM5.9823 mL29.9115 mL59.8229 mL299.1146 mL
5 mM1.1965 mL5.9823 mL11.9646 mL59.8229 mL
10 mM0.5982 mL2.9911 mL5.9823 mL29.9115 mL
20 mM0.2991 mL1.4956 mL2.9911 mL14.9557 mL

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