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1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 g | $31 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | 1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities. |
In vitro | 1-Dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. 1-Dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4]. |
In vivo | The hypocholesterolaemic activity of 1-dodecylimidazole partly arises from inhibiting cholesterol biosynthesis at the 2,3-oxidosqualene sterol cyclase level[2]. Administration of 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) results in lower serum cholesterol concentrations compared to control rats[2]. |
Molecular Weight | 236.4 |
Formula | C15H28N2 |
Cas No. | 4303-67-7 |
Smiles | CCCCCCCCCCCCn1ccnc1 |
Relative Density. | 0.9624 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (423.01 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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