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Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $55 | In Stock | |
500 mg | $74 | In Stock | |
1 mL x 10 mM (in DMSO) | $44 | In Stock |
Description | 1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lysosomal membrane and facilitates the release of cysteine proteases into the cytoplasm. Additionally, 1-Dodecylimidazole exhibits hypocholesterolemic and broad-spectrum antifungal activities. |
In vitro | N-dodecylimidazole acts as an acid-activated detergent, possessing a pKa of 6.3, and exhibits cytotoxic properties towards cultured cells. Its cytotoxic effects on EMT-6 and MGH U1 cells are dependent on extracellular pH (pHe), demonstrating dose-dependent cell mortality significantly amplified at pHe 6.0, being 100-fold more potent compared to pHe 7.0. |
In vivo | The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase[2].1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats[2]. |
Molecular Weight | 236.4 |
Formula | C15H28N2 |
Cas No. | 4303-67-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (423.01 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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