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1-Dodecylimidazole

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Catalog No. T37885Cas No. 4303-67-7

1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.

1-Dodecylimidazole

1-Dodecylimidazole

🥰Excellent
Purity: 99.09%
Catalog No. T37885Cas No. 4303-67-7
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.
Pack SizePriceAvailabilityQuantity
1 g$31 In Stock
1 mL x 10 mM (in DMSO)$39 In Stock
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Purity:99.09%
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Product Introduction

Bioactivity
Description
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.
In vitro
1-Dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. 1-Dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4].
In vivo
The hypocholesterolaemic activity of 1-dodecylimidazole partly arises from inhibiting cholesterol biosynthesis at the 2,3-oxidosqualene sterol cyclase level[2]. Administration of 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) results in lower serum cholesterol concentrations compared to control rats[2].
Chemical Properties
Molecular Weight236.4
FormulaC15H28N2
Cas No.4303-67-7
SmilesCCCCCCCCCCCCn1ccnc1
Relative Density.0.9624 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (423.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2301 mL21.1506 mL42.3012 mL211.5059 mL
5 mM0.8460 mL4.2301 mL8.4602 mL42.3012 mL
10 mM0.4230 mL2.1151 mL4.2301 mL21.1506 mL
20 mM0.2115 mL1.0575 mL2.1151 mL10.5753 mL
50 mM0.0846 mL0.4230 mL0.8460 mL4.2301 mL
100 mM0.0423 mL0.2115 mL0.4230 mL2.1151 mL

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